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PROTO-ONCOGENE PROTEINS C-KIT
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DeCS
Descriptor
English
:
Proto-Oncogene Proteins c-kit
Descriptor
Spanish
:
Proteínas Proto-Oncogénicas c-kit
Descriptor
Portuguese
:
Proteínas Proto-Oncogênicas c-kit
Synonyms
English
:
Antigens, CD117
CD117 Antigens
Receptor, Stem Cell Factor
Stem Cell Factor Receptor
c-kit Protein
c-kit Receptor
kit Proto-Oncogene Protein
p145(c-kit)
Tree Number:
D08.811.913.696.620.682.725.400.050
D12.776.543.750.060.124
D12.776.543.750.705.852.150.100
D12.776.543.750.750.400.200.170
D12.776.624.664.700.183
D23.050.301.264.035.590
D23.101.100.110.590
Definition
English
:
A protein-tyrosine kinase receptor that is specific for
STEM CELL FACTOR
. This interaction is crucial for the development of hematopoietic, gonadal, and pigment
stem cells
. Genetic mutations that disrupt the expression of
PROTO-ONCOGENE PROTEINS C-KIT
are associated with
PIEBALDISM
, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.
See Related
English
:
Piebaldism
History Note
English
:
2000(1996); use PROTO-ONCOGENE PROTEIN c-KIT (NM) 1989-1995
Allowable Qualifiers
English
:
administration & dosage
adverse effects
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
contraindications
drug effects
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
poisoning
radiation effects
toxicity
therapeutic use
ultrastructure
urine
Record Number:
32639
Unique Identifier:
D019009
Occurrence in VHL
:
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